A generalized epistasis analysis as a method of reconstruction of developmental process and its application to Drosophila dorso-ventral axis formation.

Abstract excerpt

Epistasis analysis has been used in molecular genetics to infer cause and effect relationships among loci that decide a developmental fate. In this paper, in order to investigate the logical background of the rule that relates epistasis and causal relation, a mathematical epistasis analysis is formulated. An "orderliness index" is introduced by which the cause-and-effect relation can systematically be extracted...

Topics

• Animals
• Drosophila melanogaster
• Epistasis, Genetic
• Genes, Insect
• Genotype
• Models, Genetic
• Morphogenesis
• Phenotype
• Photosynthetic Reaction Center Complex Proteins
• Photosystem II Protein Complex
• Signal Transduction