Article
K(+)-channel blockers restore synaptic plasticity in the neuromuscular junction of dunce, a Drosophila learning and memory mutant.
Proceedings. Biological sciences - 22 Dec 1992
Delgado R, Latorre R, Labarca P
Abstract excerpt
The effects of K(+)-channel blockers on synaptic transmission in dunce (dnc), a Drosophila learning and memory mutant, were investigated. Larvae dnc mutants lack facilitation and post-tetanic potentiation (PTP) at their motor end-plates; dnc mutants are also deficient in a form of phosphodiesterase, and exhibit abnormally high levels of cyclic adenosine 3',5'-monophosphate (cAMP). A two-microelectrode...
Topics
- 4-Aminopyridine
- 8-Bromo Cyclic Adenosine Monophosphate
- Amifampridine
- Animals
- Drosophila
- Larva
- Learning
- Memory
- Motor Endplate
- Mutation
- Neuronal Plasticity