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Article

K(+)-channel blockers restore synaptic plasticity in the neuromuscular junction of dunce, a Drosophila learning and memory mutant.

Proceedings. Biological sciences - 22 Dec 1992

Delgado R, Latorre R, Labarca P

Abstract excerpt

The effects of K(+)-channel blockers on synaptic transmission in dunce (dnc), a Drosophila learning and memory mutant, were investigated. Larvae dnc mutants lack facilitation and post-tetanic potentiation (PTP) at their motor end-plates; dnc mutants are also deficient in a form of phosphodiesterase, and exhibit abnormally high levels of cyclic adenosine 3',5'-monophosphate (cAMP). A two-microelectrode...

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Source

Identifiers

PMID: 1362988
DOI: 10.1098/rspb.1992.0147

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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K(+)-channel blockers restore synaptic plasticity in the neuromuscular junction of dunce, a Drosophila learning and memory mutant.PMID 1362988Read ↗

Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component downregulated by cAMP.Semantic proximity Read ↗

cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: alterations in the memory mutant dunce.Semantic proximity Read ↗

Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade.Semantic proximity Read ↗

Increased calcium influx through acetylcholine receptors in dunce neurons.Semantic proximity Read ↗

Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade.Semantic proximity Read ↗

Potassium current in Drosophila neurons is increased by either dunce mutation or cyclic AMP.Semantic proximity Read ↗

A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.Semantic proximity Read ↗

Role of cAMP cascade in synaptic stability and plasticity: ultrastructural and physiological analyses of individual synaptic boutons in Drosophila memory mutants.Semantic proximity Read ↗

Adaptation and fatigue of a mechanosensory neuron in wild-type Drosophila and in memory mutants.Semantic proximity Read ↗

Synaptic ultrastructure in nerve terminals of Drosophila larvae overexpressing the learning gene dunce.Semantic proximity Read ↗

Reduced growth cone motility in cultured neurons from Drosophila memory mutants with a defective cAMP cascade.Semantic proximity Read ↗

Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants.Semantic proximity Read ↗

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