Article
Correlation between the expression of P-glycoprotein and multidrug-resistant phenotype in transitional cell carcinoma of the urinary tract.
European urology - 1 Jan 1992
Naito S, Sakamoto N, Kotoh S, Goto K, Matsumoto T, Kumazawa J
Abstract excerpt
The expression of a multidrug-resistant (MDR) gene product, P-glycoprotein, was examined immunohistochemically in 41 transitional cell carcinomas (TCCs) of the urinary tract. In 23 of these, chemosensitivity to adriamycin (ADM) and vinblastine (VBL) was also assessed by a microtiter succinate deh...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Carcinoma, Transitional Cell
- Doxorubicin
- Drug Resistance
- Humans
- Immunohistochemistry
- Membrane Glycoproteins
- Neoplasm Proteins
- Phenotype
- Urologic Neoplasms
- Vinblastine