Article
[The significance of C4 locus II deletion in IgA nephropathy and Henoch-Schonlein nephritis and it's correlation with other HLA genes].
Nihon rinsho. Japanese journal of clinical medicine - 1 Dec 1992
Kohsaka T, Jin D K, Abe J
Abstract excerpt
IgA nephropathy and HSP nephritis share some similar immunological abnormalities, for example, high IgA serum concentration, existence of IgA-IC, alternative pathway activation, monocyte and B-cell activation and the same histological findings of renal biopsy. The genetic factors may play an important role in both diseases. The increased frequency of homozygous null C4 phenotypes was reported in Caucasians. But...
Topics
- Chromosome Deletion
- Complement C4
- Glomerulonephritis, IGA
- HLA Antigens
- Humans
- IgA Vasculitis
- Phenotype
- Polymorphism, Restriction Fragment Length