Effects of reproductive tract glutathione enhancement and depletion on ethyl methanesulfonate-induced dominant lethal mutations in Sprague-Dawley rats.

doi:10.1002/tcm.1770120203

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Article

Effects of reproductive tract glutathione enhancement and depletion on ethyl methanesulfonate-induced dominant lethal mutations in Sprague-Dawley rats.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1992

Gandy J, Bates H K, Conder L A, Harbison R D

Abstract excerpt

The effects of altering glutathione (GSH) levels in the male reproductive tract have been studied in an attempt to establish a link between chemical-induced perturbations in glutathione and susceptibility of spermatozoa to chemical insult. Tissue GSH levels were enhanced by a treatment regimen of...

Topics

Acetylcysteine
Animals
Ethyl Methanesulfonate
Fetal Resorption
Genitalia, Male
Glutathione
Ketones
Male
Mutagens
Mutation
Rats
Rats, Sprague-Dawley

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