Pemphigus vulgaris in siblings: HLA-DR4 and HLA-DQw3 and susceptibility to pemphigus.

doi:10.1016/0190-9622(92)70168-f

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Article

Pemphigus vulgaris in siblings: HLA-DR4 and HLA-DQw3 and susceptibility to pemphigus.

Journal of the American Academy of Dermatology - 1 Aug 1992

Reohr P B, Mangklabruks A, Janiga A M, DeGroot L J, Benjasuratwong Y, Soltani K

Abstract excerpt

BACKGROUND: The association of pemphigus vulgaris with the HLA serotypes, DR4 and DRw6, and with the DQ-beta chain alleles, DQw1 and DQw3, suggests that there is a genetic predisposition to this disease. However, familial cases of pemphigus vulgaris are exceedingly rare. OBJECTIVE: We studied two...

Topics

Adult
Alleles
DNA Probes
Female
HLA-DQ Antigens
HLA-DR4 Antigen
HLA-DR6 Antigen
Humans
Pemphigus
Polymorphism, Restriction Fragment Length

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