Article
Pemphigus vulgaris in siblings: HLA-DR4 and HLA-DQw3 and susceptibility to pemphigus.
Journal of the American Academy of Dermatology - 1 Aug 1992
Reohr P B, Mangklabruks A, Janiga A M, DeGroot L J, Benjasuratwong Y, Soltani K
Abstract excerpt
BACKGROUND: The association of pemphigus vulgaris with the HLA serotypes, DR4 and DRw6, and with the DQ-beta chain alleles, DQw1 and DQw3, suggests that there is a genetic predisposition to this disease. However, familial cases of pemphigus vulgaris are exceedingly rare. OBJECTIVE: We studied two siblings with pemphigus vulgaris and three unaffected family members to determine whether an HLA allele was associated...
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