The relationship of quantitative nuclear morphology to molecular genetic alterations in the adenoma-carcinoma sequence of the large bowel.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The relationship of quantitative nuclear morphology to molecular genetic alterations in the adenoma-carcinoma sequence of the large bowel.

The American journal of pathology - 1 Oct 1992

Mulder J W, Offerhaus G J, de Feyter E P, Floyd J J, Kern S E, Vogelstein B, Hamilton S R

Abstract excerpt

The relationship of abnormal nuclear morphology to molecular genetic alterations that are important in colorectal tumorigenesis is unknown. Therefore, Feulgen-stained isolated nuclei from 22 adenomas and 42 carcinomas that had been analyzed for ras gene mutations and allelic deletions on chromosomes 5q, 18q, and 17p were characterized by computerized image analysis. Both nuclear area and the nuclear shape factor...

Topics

Adenoma
Aged
Carcinoma
Cell Nucleus
Chromosome Deletion
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 5
Colorectal Neoplasms
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Humans

Image Processing, Computer-Assisted

Male

Mutation

Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 1357973
PMCID: PMC1886650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1357973-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

The relationship of quantitative nuclear morphology to molecular genetic alterations in the adenoma-carcinoma sequence of the large bowel.PMID 1357973Read ↗

Correlation between the presence of KRAS mutation and the morphometric characteristics of colorectal carcinoma cell nuclei.Semantic proximity Read ↗

The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma.Semantic proximity Read ↗

Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy studySemantic proximity Read ↗

DNA aneuploidy in ulcerative colitis: Reproducibility, topographic distribution, and relation to dysplasiaSemantic proximity Read ↗

Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model.Semantic proximity Read ↗

Nuclear morphometric analysis (NMA): screening of senescence, apoptosis and nuclear irregularities.Semantic proximity Read ↗

Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology–molecular associations: clinical and biological implicationsSemantic proximity Read ↗

Pathogenetic mechanisms of nuclear pleomorphism of tumour cells based on the mutator phenotype theory of carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.