Correlation between the presence of KRAS mutation and the morphometric characteristics of colorectal carcinoma cell nuclei.

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Article

Correlation between the presence of KRAS mutation and the morphometric characteristics of colorectal carcinoma cell nuclei.

Analytical and quantitative cytopathology and histopathology - 1 Feb 2014

Greenberg Ariel, Hershkovitz Dov, Sabo Edmond

Abstract excerpt

OBJECTIVE: To determine whether there is an association between KRAS status and changes in nuclear morphometric properties. STUDY DESIGN: A total of 60 cases were included in the analysis. Thirty cases carried a mutated KRAS oncogene, while 30 bore a wild-type KRAS gene. Computerized morphometry was used to measure various nuclear indices of size, shape, and texture. RESULTS: Nuclear ellipticity (p = 0.02) and...

Topics

Cell Nucleus
Chromatin
Colorectal Neoplasms
Databases, Factual
Humans
Image Processing, Computer-Assisted
Models, Biological
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ROC Curve
Sensitivity and Specificity
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 24902368

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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