Article
Correlation between the presence of KRAS mutation and the morphometric characteristics of colorectal carcinoma cell nuclei.
Analytical and quantitative cytopathology and histopathology - 1 Feb 2014
Greenberg Ariel, Hershkovitz Dov, Sabo Edmond
Abstract excerpt
OBJECTIVE: To determine whether there is an association between KRAS status and changes in nuclear morphometric properties. STUDY DESIGN: A total of 60 cases were included in the analysis. Thirty cases carried a mutated KRAS oncogene, while 30 bore a wild-type KRAS gene. Computerized morphometry was used to measure various nuclear indices of size, shape, and texture. RESULTS: Nuclear ellipticity (p = 0.02) and...
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