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Article

CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection.

Lancet (London, England) - 25 Jul 1992

Oksenhendler E, Autran B, Gorochov G, D'Agay M F, Seligmann M, Clauvel J P

Abstract excerpt

Three patients infected with human immunodeficiency virus (HIV) presented with pseudotumoral splenomegaly, CD8 lymphocytosis (3.5-5.1 x 10(9)/l), and hypergammaglobulinaemia. Spleen and bone marrow showed diffuse CD8 lymphocyte and plasma-cell infiltration. Amplification of the T-cell-receptor gamma chain gene did not reveal any clonal T-cell population. Phenotypic analysis showed a predominance of CD8/CD57...

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Identifiers

PMID: 1353138
DOI: 10.1016/0140-6736(92)90471-e

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