Article
Computational approach towards the three-dimensional structure of E. coli tyrosine aminotransferase.
FEBS letters - 20 Jul 1992
Jäger J, Solmajer T, Jansonius J N
Abstract excerpt
We present a new model for E. coli tyrosine aminotransferase based on the X-ray structures of the wild type and Val39Leu mutant of E. coli aspartate aminotransferase and computer simulation studies. Active site characteristics of the model are correlated with experimental observations on the specificity of these enzymes towards aromatic/dicarboxylic acid substrates.
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