Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate.

doi:10.1136/jmg.29.6.390

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Article

Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate.

Journal of medical genetics - 1 Jun 1992

Holder S E, Vintiner G M, Farren B, Malcolm S, Winter R M

Abstract excerpt

Three RFLPs at the TGFA locus were studied in 60 unrelated British Caucasian subjects with non-syndromic cleft lip/palate and 60 controls. A highly significant association between the TaqI RFLP and the occurrence of clefting was found (chi 2 = 15.04, p = less than 0.001). No significant associati...

Topics

Alleles
Chi-Square Distribution
Cleft Lip
Cleft Palate
Genotype
Haplotypes
Humans
Polymorphism, Restriction Fragment Length
Transforming Growth Factor alpha
White People

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