Article
Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes.
Journal of virology - 1 May 1992
Gorrell M D, Brandon M R, Sheffer D, Adams R J, Narayan O
Abstract excerpt
The lentiviruses of sheep, goats, and horses cause chronic multiorgan disease in which macrophages are highly permissive for viral replication. Monocytes, which mature into macrophages, are thought to be latently infected with lentivirus, but the extent to which other leukocytes are infected is u...
Topics
- Animals
- Antigens, CD
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Goats
- Histocompatibility Antigens
- Histocompatibility Antigens Class II
- Leukocyte Common Antigens
- Leukocytes, Mononuclear
- Lymph
- Macrophages
- Organ Specificity
- Phenotype
- Pneumonia, Progressive Interstitial, of Sheep
- Sheep
- T-Lymphocytes
- Virus Replication