Article
Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans.
Virology - 10 Oct 2010
Lay Margarita K, Atmar Robert L, Guix Susana, Bharadwaj Uddalak, He Hong, Neill Frederick H, Sastry K Jagannadha, Yao Qizhi, Estes Mary K
Abstract excerpt
Human noroviruses are difficult to study due to the lack of an efficient in vitro cell culture system or small animal model. Murine norovirus replicates in murine macrophages (MPhi) and dendritic cells (DCs), raising the possibility that human NoVs might replicate in such human cell types. To test this hypothesis, we evaluated DCs and MPhi derived from monocyte subsets and CD11c(+) DCs isolated from peripheral...
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