Article
Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1992
Weinberg A D, Whitham R, Swain S L, Morrison W J, Wyrick G, Hoy C, Vandenbark A A, Offner H
Abstract excerpt
Transforming growth factor-beta (TGF-beta) had a profound effect on the in vitro phenotypic development of Ag-activated Th cells and enhanced the in vivo effector function of these cells upon adoptive transfer. Previous studies have shown that there are two types of Th cell populations found in unimmunized animals, naive helper cells, which are short-lived and express low levels of CD44 and high levels of CD45R...
Topics
- Animals
- Antigens, CD
- CD4-Positive T-Lymphocytes
- Encephalomyelitis, Autoimmune, Experimental
- Female
- Histocompatibility Antigens
- Hypersensitivity, Delayed
- Immunologic Memory
- Immunotherapy, Adoptive