Article
Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.
The Journal of experimental medicine - 1 Jan 1992
Shalaby M R, Shepard H M, Presta L, Rodrigues M L, Beverley P C, Feldmann M, Carter P
Abstract excerpt
The HER2 protooncogene encodes a 185-kD transmembrane phosphoglycoproteins, human epidermal growth factor receptor 2 (p185HER2), whose amplified expression on the cell surface can lead to malignant transformation. Overexpression of HER2/p185HER2 is strongly correlated with progression of human ovarian and breast carcinomas. Recent studies have shown that human T cells can be targeted with bispecific antibody to...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- Breast Neoplasms
- CD3 Complex
- Cloning, Molecular
- Cytotoxicity, Immunologic
- Female