Segregation analysis of collagen genes in two families with joint hypermobility syndrome.

doi:10.1093/rheumatology/31.3.169

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Article

Segregation analysis of collagen genes in two families with joint hypermobility syndrome.

British journal of rheumatology - 1 Mar 1992

Henney A M, Brotherton D H, Child A H, Humphries S E, Grahame R

Abstract excerpt

We carried out a segregation analysis comparing the inheritance of collagen gene markers and joint hypermobility syndrome in two extended families. Our results exclude the genes encoding type III (COL3A1), type V alpha 2 chain (COL5A2) and type VI alpha 3 chain (COL6A3) unambiguously in both fami...

Topics

Adult
Aged
Alleles
Collagen
Female
Genetic Linkage
Genetic Markers
Humans
Joint Instability
Male
Middle Aged
Mutation
Pedigree
Phenotype

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