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Article

Activity of the CYP17 promoter in bovine adrenocortical cells before and after phenotypic switching.

Molecular and cellular endocrinology - 1 Nov 1992

Lala D S, Hornsby P J

Abstract excerpt

Cultured bovine adrenocortical cells reach replicative senescence after 100-120 population doublings in culture. Before reaching senescence, cells undergo high frequency phenotypic switching from CYP17+ to CYP17-, where '+' and '-' refer to the ability of intracellular cyclic AMP to induce expression of CYP17 (steroid 17 alpha-hydroxylase). We used luciferase reporter constructs to assess the activity of the...

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Identifiers

PMID: 1338723
DOI: 10.1016/0303-7207(92)90206-l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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