Article
Activity of the CYP17 promoter in bovine adrenocortical cells before and after phenotypic switching.
Molecular and cellular endocrinology - 1 Nov 1992
Lala D S, Hornsby P J
Abstract excerpt
Cultured bovine adrenocortical cells reach replicative senescence after 100-120 population doublings in culture. Before reaching senescence, cells undergo high frequency phenotypic switching from CYP17+ to CYP17-, where '+' and '-' refer to the ability of intracellular cyclic AMP to induce expres...
Topics
- Aldehyde-Lyases
- Animals
- Cattle
- Cell Division
- Cells, Cultured
- Cellular Senescence
- Cyclic AMP
- Cytochrome P-450 Enzyme System
- Gene Expression Regulation, Enzymologic
- Luciferases
- Male
- Phenotype
- Plasmids
- Promoter Regions, Genetic
- Recombinant Fusion Proteins
- Steroid 17-alpha-Hydroxylase
- Zona Fasciculata
- Zona Reticularis