Article
A model for phenotypic switching in adrenocortical cells senescing in culture.
Mechanisms of ageing and development - 1 Apr 1991
Hornsby P J, Yang L Q
Abstract excerpt
We have developed a cell model for loss of differentiated gene expression in cellular aging. Over long periods in culture, bovine adrenocortical cells lose expression of a specialized gene, steroid 17 alpha-hydroxylase. The decline in expression of 17 alpha-hydroxylase in mass cultures and clones of bovine adrenocortical cells is the result of a phenotypic switching process which yields a mixture of cells that...
Topics
- Adrenal Cortex
- Aging
- Animals
- Cattle
- Cells, Cultured
- Models, Genetic
- Phenotype
- Probability
- Software
- Steroid Hydroxylases