A model for phenotypic switching in adrenocortical cells senescing in culture.

Abstract excerpt

We have developed a cell model for loss of differentiated gene expression in cellular aging. Over long periods in culture, bovine adrenocortical cells lose expression of a specialized gene, steroid 17 alpha-hydroxylase. The decline in expression of 17 alpha-hydroxylase in mass cultures and clones of bovine adrenocortical cells is the result of a phenotypic switching process which yields a mixture of cells that...

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