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Superoxide Dismutases Are Involved in Candida albicans Biofilm Persistence against Miconazole

12 Jul 2011

Abstract excerpt

We investigated the cellular mechanisms responsible for the occurrence of miconazole-tolerant persisters in Candida albicans biofilms. Miconazole induced about 30% killing of sessile C. albicans cells at 75 μM. The fraction of miconazole-tolerant persisters, i.e., cells that can survive high doses of miconazole (0.6 to 2.4 mM), in these biofilms was 1 to 2%. Since miconazole induces reactive oxygen species (ROS)...

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PMID: 21746956
DOI: 10.1128/aac.00280-11

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