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Article

Construction and characterization of a human cytomegalovirus mutant with the UL18 (class I homolog) gene deleted.

Journal of virology - 1 Nov 1992

Browne H, Churcher M, Minson T

Abstract excerpt

The UL18 open reading frame of human cytomegalovirus (HCMV) (which encodes a product homologous to major histocompatibility complex class I heavy chains) has been disrupted by insertion of the beta-galactosidase gene under control of the major HCMV early promoter. The recombinant virus delta UL18 showed no phenotypic differences from wild-type HCMV in terms of single-step growth curves or particle/infectivity...

Topics

Base Sequence
Cells, Cultured
Cytomegalovirus
Fibroblasts
Genes, MHC Class I
Genes, Viral
Humans
Lac Operon
Major Histocompatibility Complex
Molecular Sequence Data
Mutagenesis, Insertional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Promoter Regions, Genetic

Viral Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1328689
DOI: 10.1128/JVI.66.11.6784-6787.1992
PMCID: PMC240178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1328689-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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