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Ageing of Neurospora crassa. I. Evidence for the free radical theory of ageing from studies of a natural-death mutant.

Mechanisms of ageing and development - 1 Jan 2000

Munkres K D, Minssen M

Abstract excerpt

A recessive mutant of Neurospora crassa, called natural-death, is characterized by a decreasing clonal growth potential under all nutritional conditions and the irreversible cessation of growth. The primary molecular defect of this mutant is not known. Evidence presented here, based upon measurements of the activities and thermolabilities of several enzymes, suggests that faulty protein synthesis is probably not...

Topics

Aging
Antioxidants
Cell Survival
Fluorescence
Free Radicals
Fungal Proteins
Glucosephosphate Dehydrogenase
Glutamate Dehydrogenase
Glutathione Peroxidase
Glutathione Reductase
Hot Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neurospora

Neurospora crassa

Pigments, Biological

Superoxide Dismutase

Source

Identifiers

PMID: 132583
DOI: 10.1016/0047-6374(76)90010-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-132583-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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