Pharmacogenetics of cyclic guanylate, antioxidants, and antioxidant enzymes in Neurospora.

doi:10.1016/0891-5849(90)90047-m

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Article

Pharmacogenetics of cyclic guanylate, antioxidants, and antioxidant enzymes in Neurospora.

Free radical biology & medicine - 1 Jan 1990

Munkres K D

Abstract excerpt

Previous studies indicate that antioxidant enzyme regulatory gene mutants (Age-) of Neurospora are defective in cellular longevity and development, numerous antioxienzymes, and cAMP, and that dietary cGMP confers normal longevity. Here it is shown that cGMP also phenotypically cures the developme...

Topics

Aging
Antioxidants
Cell Differentiation
Culture Media
Cyclic GMP
Free Radicals
Gene Expression Regulation, Enzymologic
Hydroxides
Hydroxyl Radical
Mutation
Neurospora
Second Messenger Systems
Superoxide Dismutase
Theophylline

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