Pharmacogenetics of cyclic guanylate, antioxidants, and antioxidant enzymes in Neurospora.

Abstract excerpt

Previous studies indicate that antioxidant enzyme regulatory gene mutants (Age-) of Neurospora are defective in cellular longevity and development, numerous antioxienzymes, and cAMP, and that dietary cGMP confers normal longevity. Here it is shown that cGMP also phenotypically cures the developmental and enzymatic defects. At least 5 of the 12 known antioxidant enzyme deficiencies are normalized by...

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