Article
Ageing of Neurospora crassa. III. Induction of cellular death and clonal senescence of an inositol-less mutant by inositol starvation and the protective effect of dietary antioxidants.
Mechanisms of ageing and development - 1 Jan 2000
Munkres K D
Abstract excerpt
Clonal growth rate and cellular viability of an inositol-less mutant of Neurospora crassa decline rapidly during deprivation of dietary inositol. Dietary antioxidants, either nordihydroguaiaretic acid, vitamin E or 3,5-ditert.-butyl-4-hydroxybenzyl alcohol, protected cells and clones of the mutant from death and senescence. Membrane deterioration with associated lipid autoxidation and consequent deleterious free...
Topics
- Antioxidants
- Benzyl Alcohols
- Catechols
- Inositol
- Mutation
- Neurospora
- Neurospora crassa
- Vitamin E