Gonococcal porin vaccine evaluation: comparison of Por proteosomes, liposomes, and blebs isolated from rmp deletion mutants.

doi:10.1093/infdis/166.3.551

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Article

Gonococcal porin vaccine evaluation: comparison of Por proteosomes, liposomes, and blebs isolated from rmp deletion mutants.

The Journal of infectious diseases - 1 Sept 1992

Wetzler L M, Blake M S, Barry K, Gotschlich E C

Abstract excerpt

The gonococcal major outer membrane protein, Por (protein I), is a potential vaccine candidate. A large-scale animal trial compared the immunogenicity of Por inserted in liposomes (mimicking its in vivo structure) with previously used vaccines containing Por. Por was purified from Rmp (protein II...

Topics

Adjuvants, Immunologic
Animals
Bacterial Outer Membrane Proteins
Bacterial Vaccines
Cell Membrane
Female
Liposomes
Mutation
Neisseria gonorrhoeae
Porins
Proteolipids
Rabbits

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