Article
Genetic analysis of Pseudomonas aeruginosa adherence: distinct genetic loci control attachment to epithelial cells and mucins.
Infection and immunity - 1 Sept 1992
Simpson D A, Ramphal R, Lory S
Abstract excerpt
Infection of mucosal tissues by the opportunistic pathogen Pseudomonas aeruginosa is initiated by attachment of the bacterium to host tissues. To gain a better understanding of this interaction, we used two methods to isolate mutants of P. aeruginosa with altered adherence to cultured A549 cells and to mucins. First, from a population of nonpiliated mutants of P. aeruginosa mutagenized with transposon Tn5G, we...
Topics
- Bacterial Adhesion
- Chromosome Mapping
- DNA Transposable Elements
- Epithelium
- Genes, Bacterial
- Genetic Complementation Test
- Mucins
- Mutation
- Pseudomonas aeruginosa