Article
Conjugative type IVb pilus recognizes lipopolysaccharide of recipient cells to initiate PAPI-1 pathogenicity island transfer in Pseudomonas aeruginosa.
BMC microbiology - 7 Feb 2017
Hong Toan Phuoc, Carter Michelle Q, Struffi Paolo, Casonato Stefano, Hao Youai, Lam Joseph S, Lory Stephen, Jousson Olivier
Abstract excerpt
BACKGROUND: Pseudomonas aeruginosa pathogenicity island 1 (PAPI-1) is one of the largest genomic islands of this important opportunistic human pathogen. Previous studies have shown that PAPI-1 encodes several putative virulence factors, including a major regulator of biofilm formation and antibiotic-resistance traits. PAPI-1 is horizontally transferable into recipient strains lacking this island via conjugation...
Topics
- Bacterial Proteins
- Cell Membrane
- Chromosomes, Bacterial
- Conjugation, Genetic
- Fimbriae, Bacterial
- Gene Expression Regulation, Bacterial
- Gene Transfer, Horizontal
- Genome, Bacterial
- Genomic Islands
- Humans
- Lipopolysaccharides
- Multigene Family