Article
An unusual pagC::TnphoA mutation leads to an invasion- and virulence-defective phenotype in Salmonellae.
Infection and immunity - 1 Sept 1992
Miller V L, Beer K B, Loomis W P, Olson J A, Miller S I
Abstract excerpt
Two phenotypes believed to contribute to the pathogenesis of Salmonella infections are macrophage survival and invasion of epithelial cells. It was recently observed that the Salmonella macrophage survival factor PagC has significant amino acid similarity to the Yersinia invasion factor Ail. This observation raised the possibilities that macrophage survival is in part determined by the pathway of entry and that...
Topics
- Alkaline Phosphatase
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Transposable Elements
- Female
- Genes, Bacterial
- Humans
- Mice
- Mice, Inbred BALB C