Article
The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host.
Journal of bacteriology - 1 Jul 2009
Webber Mark A, Bailey Andrew M, Blair Jessica M A, Morgan Eirwen, Stevens Mark P, Hinton Jay C D, Ivens Al, Wain John, Piddock Laura J V
Abstract excerpt
The mechanisms by which RND pumps contribute to pathogenicity are currently not understood. Using the AcrAB-TolC system as a paradigm multidrug-resistant efflux pump and Salmonella enterica serovar Typhimurium as a model pathogen, we have demonstrated that AcrA, AcrB, and TolC are each required for efficient adhesion to and invasion of epithelial cells and macrophages by Salmonella in vitro. In addition, AcrB and...
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