Article
Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches.
Molecular microbiology - 1 May 1997
Penheiter K L, Mathur N, Giles D, Fahlen T, Jones B D
Abstract excerpt
Salmonella typhimurium initiates infection of a host by invading M cells of Peyer's patches within the small intestine. The ability of the bacteria to invade mammalian cells has been shown to be regulated by environmental conditions, including oxygen concentrations, osmolarity, and growth phase....
Topics
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Cells, Cultured
- Cloning, Molecular
- DNA Transposable Elements
- Genes, Bacterial
- Genetic Complementation Test
- Ileum
- Mice
- Mice, Inbred BALB C
- Microscopy, Electron
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Peyer's Patches
- Salmonella Infections, Animal
- Salmonella typhimurium