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Article

Large-Scale Identification of Virulence Genes from <i>Streptococcus pneumoniae</i>

1 Dec 1998

Abstract excerpt

Streptococcus pneumoniae is the major cause of bacterial pneumonia, and it is also responsible for otitis media and meningitis in children. Apart from the capsule, the virulence factors of this pathogen are not completely understood. Recent technical advances in the field of bacterial pathogenesis (in vivo expression technology and signature-tagged mutagenesis [STM]) have allowed a large-scale identification of...

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PMID: 9826334
DOI: 10.1128/iai.66.12.5620-5629.1998

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