Functional genomics approach to the identification of virulence genes involved in Edwardsiella tarda pathogenesis.

doi:10.1128/IAI.71.3.1343-1351.2003

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Article

Functional genomics approach to the identification of virulence genes involved in Edwardsiella tarda pathogenesis.

Infection and immunity - 1 Mar 2003

Srinivasa Rao Putanae S, Lim Tit Meng, Leung Ka Yin

Abstract excerpt

Edwardsiella tarda is an important cause of hemorrhagic septicemia in fish and also of gastro- and extraintestinal infections in humans. Here, we report the identification of 14 virulence genes of pathogenic E. tarda that are essential for disseminated infection, via a genome-wide analysis. We screened 490 alkaline phosphatase fusion mutants from a library of 450,000 TnphoA transconjugants derived from strain...

Topics

Animals
Bacterial Adhesion
Bacterial Outer Membrane Proteins
Blotting, Southern
Cloning, Molecular
Edwardsiella tarda
Fishes
Genome, Bacterial
Lethal Dose 50
Mutation
Operon
Virulence

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Identifiers

PMID: 12595451
DOI: 10.1128/IAI.71.3.1343-1351.2003
PMCID: PMC148833

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