Article
Multiple biological markers in germ cell tumor patients treated with platinum-based chemotherapy.
Cancer research - 1 Jul 1992
Perera F P, Motzer R J, Tang D, Reed E, Parker R, Warburton D, O'Neill P, Albertini R, Bigbee W L, Jensen R H
Abstract excerpt
Blood samples from 36 germ cell tumor patients receiving chemotherapy with either cisplatin or carboplatin in combination with other drugs [etoposide or vinblastine, cyclophosphamide, dactinomycin, and bleomycin (VAB-6)] were analyzed for the presence of 7 different biological markers. The biomarkers included platinum-protein adducts, platinum-DNA adducts, sister chromatid exchange (SCE), micronuclei (MN), and...
Topics
- Adolescent
- Adult
- Biomarkers
- Carboplatin
- Cisplatin
- DNA
- Glycophorins
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Male
- Micronucleus Tests