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Article

Positive and negative feedback regulation of choline acetyltransferase mRNA levels in Drosophila: a study using temperature-sensitive mutants and embryo cell cultures.

Brain research. Molecular brain research - 1 Apr 1992

Tajima Y, Salvaterra P M

Abstract excerpt

Steady state levels of the mRNA coding for the neurotransmitter biosynthetic enzyme, acetylCoA-choline-O-acetyltransferase (ChAT, EC 2.3.1.6), were measured in wild type Drosophila and two temperature-sensitive mutants (Chats1 and Chats2) using the RNase protection method. At a permissive temperature the relative amounts of ChAT mRNA were: wild type: Chats1:Chats2 = 1:2.09 (+/- 0.39):3.37 (+/- 0.57) (mean +/-...

Topics

Alleles
Animals
Carbachol
Cells, Cultured
Choline O-Acetyltransferase
Drosophila melanogaster
Feedback
Gene Expression Regulation, Enzymologic
Mutation
Nerve Tissue Proteins
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Synaptic Transmission

Temperature

Transcription, Genetic

Tubocurarine

Source

Identifiers

PMID: 1317495
DOI: 10.1016/0169-328x(92)90029-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1317495-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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