Article
Regulation of the Na,K-ATPase activity of Madin-Darby canine kidney cells in defined medium by prostaglandin E1 and 8-bromocyclic AMP.
Journal of cellular physiology - 1 May 1992
Taub M L, Wang Y, Yang I S, Fiorella P, Lee S M
Abstract excerpt
The role of PGE1 in regulating the activity of the Na+, K(+)-ATPase in Madin Darby Canine Kidney (MDCK) cells has been examined. PGE1 increased the initial rate of ouabain-sensitive Rb+ uptake by MDCK cells, a process that continued to occur over a 5-day period. The increase in the initial rate of ouabain-sensitive Rb+ uptake in MDCK cells treated with PGE1 could be explained by a 1.6-fold increase in the Vmax...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Alprostadil
- Animals
- Bucladesine
- Cell Line
- Culture Media
- Dogs
- Drug Resistance
- Genetic Variation
- Intracellular Membranes
- Ions