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Article

Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.

Journal of virology - 1 Apr 1992

Sawtell N M, Thompson R L

Abstract excerpt

Defined herpes simplex virus type 1 (HSV-1) mutants KOS/1 and KOS/62 (positive and negative, respectively, for latency-associated transcripts [LATs]) express the Escherichia coli beta-galactosidase (beta-Gal) gene during latency. These mutants were employed to assess the functions of the latency-associated transcription unit on establishment and maintenance of and reactivation from the latent state. It was found...

Topics

Animals
Base Sequence
Blotting, Southern
DNA, Viral
Ganglia
Herpes Simplex
Kinetics
Male
Mice
Molecular Sequence Data
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Transcription, Genetic

Virus Activation

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1312626
DOI: 10.1128/JVI.66.4.2157-2169.1992
PMCID: PMC289008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1312626-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.PMID 1312626Read ↗

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Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses.Semantic proximity Read ↗

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