Article
Targeted disruption of the ABP-120 gene leads to cells with altered motility.
The Journal of cell biology - 1 Feb 1992
Cox D, Condeelis J, Wessels D, Soll D, Kern H, Knecht D A
Abstract excerpt
The actin-binding protein ABP-120 has been proposed to play a role in cross-linking F-actin filaments during pseudopod formation in motile Dictyostelium amebas. We have tested this hypothesis by analyzing the phenotype of mutant cell lines which do not produce ABP-120. Two different transformatio...
Topics
- Actins
- Animals
- Blotting, Northern
- Carrier Proteins
- Cell Line
- Cell Movement
- Chemotaxis
- Cyclic AMP
- Cytoskeleton
- Dictyostelium
- Genetic Vectors
- Microfilament Proteins
- Mutation
- Phenotype
- Pseudopodia
- Transformation, Genetic