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Article

Targeted disruption of the ABP-120 gene leads to cells with altered motility.

The Journal of cell biology - 1 Feb 1992

Cox D, Condeelis J, Wessels D, Soll D, Kern H, Knecht D A

Abstract excerpt

The actin-binding protein ABP-120 has been proposed to play a role in cross-linking F-actin filaments during pseudopod formation in motile Dictyostelium amebas. We have tested this hypothesis by analyzing the phenotype of mutant cell lines which do not produce ABP-120. Two different transformation vectors capable of targeted disruption of the ABP-120 gene locus have been constructed using a portion of an ABP-120...

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Identifiers

PMID: 1310321
DOI: 10.1083/jcb.116.4.943
PMCID: PMC2289347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted disruption of the ABP-120 gene leads to cells with altered motility.PMID 1310321Read ↗

Three actin cross-linking proteins, the 34 kDa actin-bundling protein, alpha-actinin and gelation factor (ABP-120), have both unique and redundant roles in the growth and development of Dictyostelium.Semantic proximity Read ↗

Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility.Semantic proximity Read ↗

A Dictyostelium mutant lacking an F-actin cross-linking protein, the 120-kD gelation factor.Semantic proximity Read ↗

How a cell crawls and the role of cortical myosin II.Semantic proximity Read ↗

Cross-linking of actin filaments by myosin II is a major contributor to cortical integrity and cell motility in restrictive environments.Semantic proximity Read ↗

Intracellular vesicle movement, cAMP and myosin II in Dictyostelium.Semantic proximity Read ↗

The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of <i>Dictyostelium</i> amoebae during chemotaxisSemantic proximity Read ↗

Myosin II heavy chain null mutant of Dictyostelium exhibits defective intracellular particle movement.Semantic proximity Read ↗

Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium.Semantic proximity Read ↗

cAMP stimulation of Dictyostelium discoideum destabilizes the mRNA for 117 antigen.Semantic proximity Read ↗

Mutants in the Dictyostelium Arp2/3 complex and chemoattractant-induced actin polymerization.Semantic proximity Read ↗

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