Inhibition of herpes simplex virus production in vitro by cyclosporin A.

doi:10.1007/BF01321118

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Article

Inhibition of herpes simplex virus production in vitro by cyclosporin A.

Archives of virology - 1 Jan 1992

Vahlne A, Larsson P A, Horal P, Ahlmén J, Svennerholm B, Gronowitz J S, Olofsson S

Abstract excerpt

Nontoxic concentrations of Cyclosporin A (CyA) dose-dependently inhibited herpes simplex virus (HSV) production in resting monkey kidney cells. The block was at the step of virus DNA synthesis as assessed by [3H]thymidine incorporation and by dot blot hybridization of infected cell DNA using a cl...

Topics

Animals
Antiviral Agents
Cells, Cultured
Cyclosporine
DNA, Viral
DNA-Directed DNA Polymerase
Drug Resistance
Mutation
Simplexvirus
Thymidine Kinase
Viral Proteins
Virus Replication

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