Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

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Article

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

The Journal of biological chemistry - 8 Jul 1994

Bosma P J, Seppen J, Goldhoorn B, Bakker C, Oude Elferink R P, Chowdhury J R, Chowdhury N R, Jansen P L

Abstract excerpt

Crigler-Najjar syndrome type I (CN-I) is caused by an inherited absence of UDP-glucuronosyltransferase activity toward bilirubin (B-UGT), resulting in severe non-hemolytic unconjugated hyperbilirubinemia. Based on the expression of cDNAs in COS cells, two UGT isoforms in human liver, B-UGT1 and B...

Topics

Animals
Base Sequence
Bilirubin
Catalysis
Cell Line
Cloning, Molecular
Crigler-Najjar Syndrome
Exons
Glucuronosyltransferase
Humans
Isoenzymes
Liver
Mutation
Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 8027054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8027054-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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