Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-based mutagenesis of the malonyl-CoA:acyl carrier protein transacylase from Streptomyces coelicolor.

Biochemistry - 23 Sept 2003

Koppisch Andrew T, Khosla Chaitan

Abstract excerpt

Malonyl-CoA:acyl carrier protein transacylase (MAT) provides acyl-ACP thioesters for the biosynthesis of aromatic polyketides, and thus is the primary gatekeeper of substrate specificity in type II PKS. A recent report described the X-ray crystal structure of the Streptomyces coelicolor MAT and s...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Circular Dichroism
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Models, Chemical

Share to Mutagenesis

Share to Naphthoquinones

Share to Streptomyces

Source

Identifiers

PMID: 12974642
DOI: 10.1021/bi0349672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12974642-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-based mutagenesis of the malonyl-CoA:acyl carrier protein transacylase from Streptomyces coelicolor.PMID 12974642Read ↗

Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.Semantic proximity Read ↗

Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III.Semantic proximity Read ↗

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.Semantic proximity Read ↗

Catalysis and mechanism of malonyl transferase activity in type II fatty acid biosynthesis acyl carrier proteins.Semantic proximity Read ↗

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.Semantic proximity Read ↗

Methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis: substrate specificity and coenzyme A binding.Semantic proximity Read ↗

The malonyl transferase activity of type II polyketide synthase acyl carrier proteins.Semantic proximity Read ↗

Improving the substrate binding of acetyl-CoA carboxylase (AccB) from Streptomyces antibioticus through computational enzyme engineering.Semantic proximity Read ↗

Alanine-scanning mutagenesis of protein mannosyl-transferase from Streptomyces coelicolor reveals strong activity-stability correlation.Semantic proximity Read ↗

Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa.Semantic proximity Read ↗

ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones.Semantic proximity Read ↗

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.