Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synchronization of interphase events depends neither on mitosis nor on cdk1.

Molecular biology of the cell - 1 Sept 2003

Laronne Ayelet, Rotkopf Shay, Hellman Asaf, Gruenbaum Yosef, Porter Andrew C G, Brandeis Michael

Abstract excerpt

Human HT2-19 cells with a conditional cdk1 mutation stop dividing upon cdk1 inactivation and undergo multiple rounds of endoreplication. We show herein that major cell cycle events remain synchronized in these endoreplicating cells. DNA replication alternates with gap phases and cell cycle-specific cyclin E expression is maintained. Centrosomes duplicate in synchrony with chromosome replication, giving rise to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cdc20 Proteins
Share to Cyclin A
Share to Cyclin B1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin E

Share to Interphase

Share to Nuclear Lamina

Share to Nuclear Pore

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 12972560
DOI: 10.1091/mbc.e02-12-0850
PMCID: PMC196563

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synchronization of interphase events depends neither on mitosis nor on cdk1.PMID 12972560Read ↗

Cyclin B1–Cdk1 Activation Continues after Centrosome Separation to Control Mitotic ProgressionSemantic proximity Read ↗

Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosisSemantic proximity Read ↗

Developmentally programmed endoreduplication in animalsSemantic proximity Read ↗

CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic CentrosomesSemantic proximity Read ↗

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signalingSemantic proximity Read ↗

Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos.Semantic proximity Read ↗

Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.Semantic proximity Read ↗

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cellsSemantic proximity Read ↗

A Moonlighting Function of Kinetochore Complex Proteins in Golgi Assembly of Neural Stem CellsSemantic proximity Read ↗

Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content.Semantic proximity Read ↗

Cell Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid CellsSemantic proximity Read ↗

Endomitosis of Human Megakaryocytes Are Due to Abortive MitosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.