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Article

The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma

9 Nov 2016

Abstract excerpt

Regulatory factor X-5 (RFX5) was previously characterized as an essential and highly specific regulator of major histocompatibility class II (MHCII) gene expression in the immune system. We found that RFX5 is significantly upregulated in hepatocellular carcinoma (HCC) tumors and cell lines compared with non-tumor tissues in mRNA expression levels, but it fails to induce the expression of MHCII. However, RFX5 can...

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PMID: 27840983
DOI: 10.3892/or.2016.5240

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