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Article

A methylation-responsive MDBP/RFX site is in the first exon of the collagen alpha2(I) promoter.

The Journal of biological chemistry - 17 Dec 1999

Sengupta P K, Ehrlich M, Smith B D

Abstract excerpt

DNA methylation inhibits transcription driven by the collagen alpha2(I) promoter and the 5' end of the gene in transient transfection and in vitro transcription assays. DNA-binding proteins in a unique family of ubiquitously expressed proteins, methylated DNA-binding protein (MDBP)/regulatory factor for X box (RFX), form specific complexes with a sequence overlapping the transcription start site of the collagen...

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Identifiers

PMID: 10593968
DOI: 10.1074/jbc.274.51.36649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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