Article
Mesenchymal stromal cells expanded in human allogenic cord blood serum display higher self-renewal and enhanced osteogenic potential.
Stem cells and development - 1 May 2009
Jung Jooyoung, Moon Noory, Ahn Ji-Yeon, Oh Eun-Jee, Kim Myungshin, Cho Chul-Soo, Shin Jong-Chul, Oh Il-Hoan
Abstract excerpt
Recent clinical trials using ex vivo expanded mesenchymal stromal cells (MSCs) have raised interest in the safety and function of cultured MSCs. Here, to assess the feasibility of using allogenic human umbilical cord blood serum (CBS) for humanized clinical-grade expansion of MSCs, we characterized MSCs expanded in CBS and compared them to MSCs expanded in fetal bovine serum (FBS). MSCs in CBS exhibited a higher...
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