Article
Protein C and protein S assessment in hospital laboratories: which strategy and what role for DNA sequencing?
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2003
Labrouche Sylvie, Reboul Marie-Pierre, Guérin Viviane, Vergnes Christine, Freyburger Geneviève
Abstract excerpt
This paper presents a critical assessment of protein C (PC) and protein S (PS) functional and immunological approaches with regard to DNA sequencing in a large hospital recruitment for thrombosis exploration in more than 1700 consecutive patients. After examination of clinical status and PC and PS phenotype, a genotypic study was implemented for 17 PC-deficient and 28 PS-deficient patients (activity < 70%)....
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