Article
PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency.
Thrombosis and haemostasis - 1 Mar 2016
Alhenc-Gelas Martine, Plu-Bureau Genevieve, Horellou Marie Hélène, Rauch Antoine, Suchon Pierre
Abstract excerpt
Inherited protein S deficiency (PSD) is an established risk factor for venous thromboembolism (VTE). However, data are conflicting concerning risk of VTE associated with decreased free PS level (FPS) and information on PROS1 genotype-phenotype relationship is sparse. In a retrospective cohort of 579 patients with inherited type I/III deficiency suspicion, PROS1 genotyping was performed and the effect of genotype...
Topics
- Adult
- Female
- Genetic Association Studies
- Genotype
- Humans
- Male
- Middle Aged
- Mutation
- Protein S
- Protein S Deficiency
- Retrospective Studies
- Risk Factors
- Thrombophilia
- Thrombosis
- Venous Thromboembolism
- Venous Thrombosis
- Young Adult