Early reconstitution of the T‐cell repertoire after non‐myeloablative peripheral blood stem cell transplantation is from post‐thymic T‐cell expansion and is unaffected by graft‐versus‐host disease or mixed chimaerism

Abstract excerpt

To study immune recovery after non-myeloablative, reduced-intensity stem cell allografts (NST) and T-cell-depleted myeloablative transplants (TCD), we measured T-cell subset recovery by flow cytometry, T-cell repertoire by spectratyping and thymic T-cell output using a T-cell receptor excision circle (TREC) assay. We found a rapid and comparable increase in lymphocyte numbers in both NST and TCD, supporting the...

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