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Article

Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients.

The Journal of experimental medicine - 7 Mar 2005

Muraro Paolo A, Douek Daniel C, Packer Amy, Chung Katherine, Guenaga Francisco J, Cassiani-Ingoni Riccardo, Campbell Catherine, Memon Sarfraz, Nagle James W, Hakim Frances T, Gress Ronald E, McFarland Henry F, Burt Richard K, Martin Roland

Abstract excerpt

Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT) can persistently suppress inflammatory disease activity in a subset of patients with severe multiple sclerosis (MS), but the mechanism has remained unclear. To understand whether the beneficial effects on the course of disease are mediated by lympho-depletive effects alone or are sustained by a regeneration of the immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15738052
DOI: 10.1084/jem.20041679
PMCID: PMC2212822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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