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A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse

3 Sept 2003

Abstract excerpt

The transcription factor Gata1 is essential for the development of erythroid cells. Consequently, Gata1 null mutants die in utero due to severe anaemia. Outside the haematopoietic system, Gata1 is only expressed in the Sertoli cells of the testis. To elucidate the function of Gata1 in the testis, we made a Sertoli cell-specific knockout of the Gata1 gene in the mouse. We deleted a normally functioning 'floxed'...

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PMID: 12954777
DOI: 10.1093/nar/gkg723

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