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Article

Reciprocal Inhibition between MyoD and STAT3 in the Regulation of Growth and Differentiation of Myoblasts

1 Nov 2003

Abstract excerpt

The development of myoblasts is regulated by various growth factors as well as by intrinsic muscle-specific transcriptional factors. In this study, we analyzed the roles for STAT3 in the growth and differentiation of myoblasts in terms of cell cycle regulation and interaction with MyoD using C2C12 cells. Here we found that STAT3 inhibited myogenic differentiation induced by low serum or MyoD as efficiently as the...

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PMID: 12947115
DOI: 10.1074/jbc.m304884200

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Related research

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Research trail→

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Reciprocal Inhibition between MyoD and STAT3 in the Regulation of Growth and Differentiation of MyoblastsPMID 12947115Read ↗

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Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase.Semantic proximity Read ↗

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Autonomous differentiation in the mouse myogenic cell line, C2, involves a mutual positive control between insulin-like growth factor II and MyoD, operating as early as at the myoblast stageSemantic proximity Read ↗

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