Article
Evidence of a substantial genetic basis for IgG2 levels in families with aggressive periodontitis.
Journal of dental research - 1 Sept 2003
Diehl S R, Wu T, Burmeister J A, Califano J V, Brooks C N, Tew J G, Schenkein H A
Abstract excerpt
IgG2 is elevated in localized but not in generalized aggressive periodontitis (AgP). Exposure to pathogenic bacteria is essential for disease. Immune responses are dominated by IgG2 reactive with bacterial surface carbohydrates. We used variance component analyses to assess IgG2 heritability and determine whether genes that influence IgG2 are the same genes that influence disease susceptibility. We studied 17...
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